On one hand, I never paid much mind to the differences between PC and Mac modifier keys. And for the most part, if you just s/control/super/g most things will feel at home.
On the other hand, I’m pretty sure that the remapping of my various keyboards ctrl/super/alt based on how Macs do things, will confound and give me headaches when movements become like super+arrow = home ; alt+arrow = move by word; rather than fn+arrow = home; ctrl+arrow = move by word ; etc.
And then there is the fact that the key map in my head is basically an XFree86 key mapping....lol.
Because for the most part, I have lived in the land that Unix and CP/M wrought. Thus whenever I use quick editing shortcuts that are universal to GUI apps, as opposed to inspired by vi and emacs, I am very, very, very quick to execute actions like shift ctrl+left+left to select the previous two words.
If I am found laying on the floor, twitching, it’s probably Google’s fault. If I’m found laying on the floor spinning in circles, it’s probably because my Bluetooth keyboards are shared between a PC, and an iPad, and third things that are like PCs.